T-Cell Stages


  • T Cell Stages
    • Development in stages
      • Immature T-cells produced in bone marrow
      • Matures in thymus
        • Undergo a 2-step process of clonal selection
          • Positive selection tests whether T cells can successfully recognize MHC molecules
            • Failure in positive selection makes T cells unable to bind antigen or launch adaptive immune response against foreign invaders
          • Negative selection tests whether T cells can avoid association with self-antigens 
            • Failure in negative selection results in self-reactive or autoimmune diseases.
      • Naive T-cells (unactivated) reside in lymph tissues (lymph nodes, spleen, tonsils)
      • Activation causes proliferation and differentiation into cytotoxic, helper, or memory T-cells