MHC I and II
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- MHC (Major Histocompatibility Complex) 1 vs 2
- Surface proteins (membrane-bound) that present antigens for T-cells to inspect
- Two types
- MHC class 1 (MHC1)
- Displays antigens derived from intracellular pathogens (viruses/bacteria)
- MHC class 2 (MHC2)
- Displays antigens derived from extracellular pathogens
- Displayed only by phagocytic cells
- Cells with MHC II are called professional antigen presenting cells (APCs)
- Common APCs include macrophages, dendritic cells, and B-cells
- Cells with MHC II are called professional antigen presenting cells (APCs)
- MHC class 1 (MHC1)