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B Cell Stages

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  • B Cell Stages
    • Development occurs in stages
      • Produced in bone marrow
      • Matures in bone marrow
        • Undergo a 2-step process of clonal selection
          • Positive selection tests whether B cells can successfully recognize MHC molecules
            • Failure in positive selection makes antibodies unable to bind antigen or launch adaptive immune response against foreign invaders
          • Negative selection tests whether B cells can avoid association with self-antigens 
            • Failure in negative selection results in self-reactive or autoimmune diseases.
      • Surviving naive B-cells (unactivated) reside in lymph tissues (lymph nodes, spleen, tonsils)
      • Activated B-cells proliferate and differentiate into plasma or memory B-cells