Medicine & USMLE

Donepezil

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Neuro Drugs
  1. Levodopa, Carbidopa
  2. Levetiracetam
  3. Valproic Acid
  4. Anticholinergic Syndrome
  5. Cholinergic Crisis
  6. Benztropine / Trihexyphenidyl
  7. Lidocaine
  8. Pyridostigmine, Neostigmine, Edrophonium
  9. Naltrexone
  10. Pregabalin
  11. Scopolamine
  12. Phenytoin
  13. Ethosuximide
  14. Succinylcholine
  15. Opioids
  16. Memantine
  17. Halothane / Flurane
  18. Donepezil
  19. Propofol
  20. Ergotamine
  21. Triptans
  22. Selegiline / Rasagiline
  23. Entacapone / Tolcapone
  24. Gabapentin
  25. Lamotrigine
  26. Carbamazepine
  27. Ramelteon

Summary

Donepezil and Rivastigmine are medications that treat Alzheimer Disease by increasing the acetylcholine levels in the body. Although they are not a cure or prevention for Alzheimer disease, they can slow the progression of the disease.

Key Points

  • Donepezil (Aricept), Rivastigmine (Exelon)
    • Mechanism
      • Acetylcholinesterase inhibitor
        • Inhibits the enzyme that breaks down acetylcholine, increasing the amount of acetylcholine available at the receptor site and improving memory
    • Clinical Uses
      • Alzheimer Disease
        • Effective in mild to moderate Alzheimer’s
        • Does not cure or prevent Alzheimers, but can slow progression of the disease
    • Side Effects and Adverse Reactions
      • Gastrointestinal distress
        • Nausea, vomiting, diarrhea (frequent bowel movements)
        • Due to increases parasympathetic (rest and digest response)
      • Bradycardia
        • In patients with pre-existing heart conditions
      • Frequent Urination
        • Due to increased parasympathetic (rest and digest response)