Donepezil

Summary

Donepezil and Rivastigmine are medications that treat Alzheimer Disease by increasing the acetylcholine levels in the body. Although they are not a cure or prevention for Alzheimer disease, they can slow the progression of the disease.

Key Points

• Donepezil (Aricept), Rivastigmine (Exelon)
  • Mechanism
    • Acetylcholinesterase inhibitor
      • Inhibits the enzyme that breaks down acetylcholine, increasing the amount of acetylcholine available at the receptor site and improving memory
  • Clinical Uses
    • Alzheimer Disease
      • Effective in mild to moderate Alzheimer’s
      • Does not cure or prevent Alzheimers, but can slow progression of the disease
  • Side Effects and Adverse Reactions
    • Gastrointestinal distress
      • Nausea, vomiting, diarrhea (frequent bowel movements)
      • Due to increases parasympathetic (rest and digest response)
    • Bradycardia
      • In patients with pre-existing heart conditions
    • Frequent Urination
      • Due to increased parasympathetic (rest and digest response)