USMLE

Donepezil

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Neuro Drugs
  1. Pyridostigmine, Neostigmine, Edrophonium
  2. Valproic Acid
  3. Naltrexone
  4. Levetiracetam
  5. Pregabalin
  6. Scopolamine
  7. Phenytoin
  8. Ethosuximide
  9. Levodopa, Carbidopa
  10. Succinylcholine
  11. Memantine
  12. Donepezil
  13. Halothane / Flurane
  14. Propofol
  15. Ergotamine
  16. Triptans
  17. Selegiline / Rasagiline
  18. Entacapone / Tolcapone
  19. Gabapentin
  20. Lamotrigine
  21. Carbamazepine
  22. Mannitol
  23. Ramelteon

Summary

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Key Points

  • Donepezil (Aricept), Rivastigmine (Exelon)
    • Mechanism
      • Acetylcholinesterase inhibitor
        • Inhibits the enzyme that breaks down acetylcholine, increasing the amount of acetylcholine available at the receptor site and improving memory
    • Clinical Uses
      • Alzheimer Disease
        • Effective in mild to moderate Alzheimer’s
        • Does not cure or prevent Alzheimers, but can slow progression of the disease
    • Side Effects and Adverse Reactions
      • Gastrointestinal distress
        • Nausea, vomiting, diarrhea (frequent bowel movements)
        • Due to increases parasympathetic (rest and digest response)
      • Bradycardia
        • In patients with pre-existing heart conditions
      • Frequent Urination
        • Due to increased parasympathetic (rest and digest response)