USMLE

Threonine

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Amino Acids
  1. Serine
  2. Asparagine
  3. Alanine
  4. Valine
  5. Leucine
  6. Isoleucine
  7. Phenylalanine
  8. Tryptophan
  9. Methionine
  10. Proline
  11. Glycine
  12. Threonine
  13. Cysteine
  14. Tyrosine
  15. Glutamine
  16. Aspartate
  17. Glutamate
  18. Histidine
  19. Lysine
  20. Arginine

Summary

Threonine, which abbreviates to the 3-letters Thr or one-letter T, is one of the 20 amino acids that make up proteins in our body. Threonine’s R-group is a 2 carbon chain with a hydroxyl attached to the first carbon. Because of its hydroxyl group, threonine can be phosphorylated. Threonine is also a polar, hydrophilic amino acid, with a neutral charge at physiological pH.

Key Points

  • Threonine
    • Abbreviations
      • Thr, T
    • Chemical Structure
    • R-Group: -CH(OH)-CH3
      • Methyl group branches from β carbon
        • Contrast vs. Serine (which has no methyl group branch)
      • Hydroxyl group
        • Phosphorylatable by threonine kinases
    • Polarity
      • Polar (water soluble/hydrophilic)
    • Charge at pH 7
      • Neutral (0)