Medicine & USMLE


  1. Renin
  2. Angiotensin II
  3. Aldosterone
  4. ADH
  5. RAAS System
  6. Kidney Overview
  7. Nephron Structure
  8. Glomerulus
  9. Proximal Tubule
  10. Loop of Henle
  11. Distal Tubule
  12. Collecting Duct
  • Renin 
    • Released by juxtaglomerular cells (located in distal tubule of the kidney) when BP is low 
      • Also activated by sympathetic nervous response 
      • Also activated when macula densa cells (in distal convoluted tubule) sense low levels of salt 
    • Eventually leads to production of angiotensin II aldosterone, ADH
      • Renin cleaves the plasma protein angiotensinogen to form angiotensin I, which is cleaved to form angiotensin II