USMLE

Angiotensin II

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Renal
  1. Renin
  2. Angiotensin II
  3. Aldosterone
  4. ADH
  5. RAAS System
  6. Kidney Overview
  7. Nephron Structure
  8. Glomerulus
  9. Proximal Tubule
  10. Loop of Henle
  11. Distal Tubule
  12. Collecting Duct
  • Angiotensin II
    • Produced from upstream action of renin
      • Renin cleaves the precursor angiotensinogen (made in liver) to form angiotensin I
      • Angiotensin-converting enzyme (ACE) from endothelial cells then cleaves angiotensin I to form angiotensin II in the lungs 
  • Angiotensin II raises BP by:
    • Inducing release of aldosterone and ADH
      • Increases BP by increasing blood volume through water retention
    • Inducing constriction of arterioles 
  • Increases BP without changing blood volume
    • Increases BP without changing blood volume
    • Increases arterial pressure in kidneys