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Angiotensin II

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  • Angiotensin II
    • Produced from upstream action of renin
      • Renin cleaves the precursor angiotensinogen (made in liver) to form angiotensin I
      • Angiotensin-converting enzyme (ACE) from endothelial cells then cleaves angiotensin I to form angiotensin II in the lungs 
  • Angiotensin II raises BP by:
    • Inducing release of aldosterone and ADH
      • Increases BP by increasing blood volume through water retention
    • Inducing constriction of arterioles 
  • Increases BP without changing blood volume
    • Increases BP without changing blood volume
    • Increases arterial pressure in kidneys