USMLE

3rd Generation Cephalosporins

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Antibiotics / Antiparasitics
  1. Penicillin Overview
  2. Penicillinase-Sensitive vs. Penicillinase-Resistant Penicillins
  3. Anti-Pseudomonal Penicillins
  4. Cephalosporins Overview
  5. 1st Generation Cephalosporins
  6. 2nd Generation Cephalosporins
  7. 3rd Generation Cephalosporins
  8. 4th Generation Cephalosporins
  9. 5th Generation Cephalosporins
  10. Carbapenems
  11. Monobactams (Aztreonam)
  12. Vancomycin
  13. Aminoglycosides
  14. Tetracyclines
  15. Tigecycline
  16. Chloramphenicol
  17. Clindamycin
  18. Linezolid
  19. Macrolides
  20. Polymyxins
  21. Sulfonamides
  22. Dapsone
  23. Trimethoprim
  24. Fluoroquinolones
  25. Daptomycin
  26. Metronidazole
  27. Rifamycins (Rifampin, Rifabutin)
  28. Isoniazid
  29. Pyrazinamide
  30. Ethambutol
  31. Chloroquine

Summary

Third generation cephalosporins are a group of beta-lactam antibiotics widely used in the hospital setting. There are two drug names in the third-generation that are important to remember - ceftriaxone and ceftazidime. These antibiotics have broad coverage, as they are effective against both gram positive and gram negative bacteria. Ceftriaxone is used to treat bacterial meningitis, Lyme disease, and gonorrhea. Ceftazidime can treat pseudomonas infections.

Key Points

  • 3rd Generation Cephalosporins
    • Drug Names
      • cefTRIAXONE 
      • cefTAZIDIME
      • CefoTAXIME
      • CefPODOXIME
      • ceFIXime
    • Mechanism
      • Same as other Cephalosporins (see: Cephalosporin Overview)
    • Clinical Use
      • Broad gram positive and negative coverage
        • Clinically used for serious gram-negative infections
      • Ceftriaxone
        • Meningitis
          • Crosses blood-brain-barrier (BBB)
        • Neisseria gonorrhoeae
        • (Disseminated) Lyme
      • Ceftazidime
        • Pseudomonas aeruginosa
    • Adverse Effects
      • Same as other Cephalosporins (see: Cephalosporin Overview)