Tetrabenazine is a drug that works by inhibiting vesicular monoamine transporter or VMAT, which decreases the packaging and release of dopamine at neuronal synapses. Reducing dopamine signaling is helpful in the treatment of movement disorders like Huntingon’s chorea and Tardive Dyskinesia, which are characterized by too much dopamine activity in the brain.

Key Points

  • Tetrabenazine
    • Mechanism
      • Inhibits vesicular monoamine transporter (VMAT) decreases dopamine release
        • Decreases dopamine vesicle packaging and release
        • Causes degradation of dopamine by monoamine oxidase
    • Clinical Use
      • Treats Huntington Chorea and Tardive Dyskinesia