Benztropine, Trihexyphenidyl

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Summary

Benztropine and Trihexyphenidyl are drugs used to treat Parkinson's disease and drug-induced Parkinsonism. They work by functioning as anticholinergic medications. Specifically, anticholinergic drugs help improve tremor and rigidity seen in Parkison’s disease and drug-induced parkinsonism. Given their mechanism, it should also make sense that benztropine and trihexyphenidyl can cause anticholinergic symptoms.

Key Points

  • Benztropine, Trihexyphenidyl
    • Mechanism
      • Act as Anticholinergic
    • Clinical Use
      • Treat tremor in Parkinson’s disease
        • Improve tremor and rigidity but have little effect on bradykinesia in Parkinson disease
        • Under normal conditions, dopamine and acetylcholine are in electrochemical balance in the basal ganglia
          • Decreased dopamine in Parkinson's disease (PD) leads to increased cholinergic sensitivity.
      • Drug-induced parkinsonism (1st line)
    • Adverse Effects:
      • Anticholinergic side effects