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Glycoprotein IIb/IIIa Inhibitors

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Summary

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Key Points

  • GP IIb/IIIa Inhibitors
    • Drug Names
      • Abciximab
      • Eptifibatide
      • Tirofiban
    • Mechanism
      • Competitively inhibit glycoprotein IIb/IIIa receptors on platelets
        • Prevents platelet aggregation
          • Normally, aggregation occurs via fibrinogen cross-linking using glycoprotein IIb/IIIa receptors
        • Similar effect to Glanzmann’s Thrombasthenia
          • Bleeding disorder in which platelets lack glycoprotein IIb/IIIa receptors
    • Clinical Use
      • Prevention of thrombosis for acute coronary syndrome
        • Especially during/after percutaneous coronary interventions (PCI), also known as stenting
        • Used to treat unstable angina and acute coronary syndrome (e.g. NSTEMI)
        • Used in high risk patients
          • Continued ischemia despite dual antiplatelet therapy
          • Large coronary thrombus or thrombotic complication during PCI
    •  Adverse Effects
      • Thrombocytopenia
      • Bleeding