Previous
Next

Togavirus

22
Watch Video

Key Points

  • Togaviruses
    • Characteristics
      • RNA viruses
        • replicate in the cytoplasm of cells
        • Single-stranded
      • + sense
      • Linear chromosome
      • Enveloped
      • Icosahedral capsid
    • Viruses of Medical importance
      • Chikungunya virus
        • Transmission
          • Arthropod-borne: Aedes mosquito
        • Presentation: Chikungunya fever
          • Flu-like illness (fever, nausea/vomiting, myalgias, malaise)
          • Polyarthralgias
          • Diffuse macular rash
      • Rubella virus
        • Transmission
          • Respiratory droplets
            • usually affects children
          • Vertical transmission
        • Presentation
          • Rubella
            • Also known as German Measles or 3-day Measles
            • Fever
            • Lymphadenopathy (esp. postauricular)
            • Arthralgias
            • Maculopapular rash
              • Starts on face and spreads downwards to involve trunk and extremities
          • Congenital Rubella
            • Sensorineural deafness
            • Cataracts
            • Cardiac malformations (e.g. PDA)
              • Close with indomethacin
            • Blueberry muffin appearance
              • due to dermal extramedullary hematopoiesis
            • Developmental delay may be seen
        • Treatment
          • Supportive
        • Prophylaxis
          • MMR vaccine (Measles, Mumps, Rubella) - live attenuated
            • Given at 12-15 months of age
            • Has greatly reduced incidence of congenital rubella
      • Eastern and Western Encephalitis