Chronic Lymphocytic Leukemia (CLL)
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Leukemias and Lymphomas
- Acute Myelogenous Leukemia (AML)
- Acute Promyelocytic Leukemia (APL)
- Acute Lymphocytic Leukemia (ALL)
- Chronic Myelogenous Leukemia (CML)
- Chronic Lymphocytic Leukemia (CLL)
- Hairy Cell Leukemia (HCL)
- Hodgkin Lymphoma
- Burkitt Lymphoma
- Diffuse Large B Cell Lymphoma (DLBCL)
- Follicular Lymphoma
- Mantle Cell Lymphoma
- Marginal Zone Lymphoma
- Primary CNS Lymphoma (PCNSL)
- Adult T-Cell Leukemia/Lymphoma (ATLL)
- Mycosis Fungoides / Sezary Syndrome
Summary
Chronic Lymphocytic Leukemia or CLL is a cancer of mature lymphocytes. Specifically, CLL affects B-cells, which express the surface markers CD20, CD23, and CD5. CLL most often occurs in the elderly, with a median age of 70 at diagnosis. Clinical findings of CLL include anemia and the presence of smudge cells on the peripheral blood smear. In some cases, CLL can transform into a more aggressive form of cancer called Diffuse Large B cell lymphoma, in a process known as the Richter Transformation.