Chronic Lymphocytic Leukemia (CLL)



Chronic Lymphocytic Leukemia or CLL is a cancer of mature lymphocytes. Specifically, CLL affects B-cells, which express the surface markers CD20, CD23, and CD5. CLL most often occurs in the elderly, with a median age of 70 at diagnosis. Clinical findings of CLL include anemia and the presence of smudge cells on the peripheral blood smear. In some cases, CLL can transform into a more aggressive form of cancer called Diffuse Large B cell lymphoma, in a process known as the Richter Transformation.