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Beta-1 Adrenergic Receptors
View this Beta-1 Adrenergic Receptors mnemonic and other USMLE mnemonics in the GPCRs (in-progress) playlist.
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Beta-1 Adrenergic Receptors

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Summary

Beta-1 adrenergic receptors are G-protein coupled receptors associated with a Gs protein subunit. Activation of the Gs subunit increases cAMP and PKA levels, leading to the phosphorylation of various intracellular proteins. Beta-1 receptors are primarily located on the heart, where their signalling causes increased heart rate and contractility. The other main function of beta-1 receptors is renin release at the kidney. Pharmacologically, beta-1 antagonists are important in the chronic management of high blood pressure and heart failure, while beta-1 agonists treat shock and decompensated heart failure in the acute setting.

Key Points

  • Beta-1 Receptors
    • Signaling
      • Use the Gs signaling pathway
    • Outcomes
      • Increased heart rate / contractility
      • Increased renin release
      • Increased lipolysis (lower yield)