USMLE

Beta-1 (Adrenergic) Receptors

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General Pharm
  1. Gs / Gi Pathway
  2. Gq Signaling Pathway
  3. Alpha-1 (Adrenergic) Receptors
  4. Alpha-2 (Adrenergic) Receptors
  5. Beta-1 (Adrenergic) Receptors
  6. Beta-2 (Adrenergic) Receptors
  7. Beta-3 (Adrenergic) Receptors
  8. M1 (Muscarinic) Receptors
  9. M2 (Muscarinic) Receptors
  10. M3 (Muscarinic) Receptors
  11. D1 (Dopamine) Receptors
  12. D2 (Dopamine) Receptors
  13. H1 (Histamine) Receptors
  14. H2 (Histamine) Receptors
  15. V1 (Vasopressin) Receptors
  16. V2 (Vasopressin) Receptors

Summary

Beta-1 adrenergic receptors are G-protein coupled receptors associated with a Gs protein subunit. Activation of the Gs subunit increases cAMP and PKA levels, leading to the phosphorylation of various intracellular proteins. Beta-1 receptors are primarily located on the heart, where their signalling causes increased heart rate and contractility. The other main function of beta-1 receptors is renin release at the kidney. Pharmacologically, beta-1 antagonists are important in the chronic management of high blood pressure and heart failure, while beta-1 agonists treat shock and decompensated heart failure in the acute setting.

Key Points

  • Beta-1 Receptors
    • Signaling
      • Use the Gs signaling pathway
    • Outcomes
      • Increased heart rate / contractility
      • Increased renin release
      • Increased lipolysis (lower yield)