Beta-1 (Adrenergic) Receptors



Beta-1 adrenergic receptors are G-protein coupled receptors associated with a Gs protein subunit. Activation of the Gs subunit increases cAMP and PKA levels, leading to the phosphorylation of various intracellular proteins. Beta-1 receptors are primarily located on the heart, where their signalling causes increased heart rate and contractility. The other main function of beta-1 receptors is renin release at the kidney. Pharmacologically, beta-1 antagonists are important in the chronic management of high blood pressure and heart failure, while beta-1 agonists treat shock and decompensated heart failure in the acute setting.

Key Points

  • Beta-1 Receptors
    • Signaling
      • Use the Gs signaling pathway
    • Outcomes
      • Increased heart rate / contractility
      • Increased renin release
      • Increased lipolysis (lower yield)