Osteoid Osteoma vs Osteoblastoma

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Osteoid Osteoma and Osteoblastoma are both benign tumors of osteoblasts, which are the osteoid-producing, bone-forming cells in the body. Since these tumors both contain osteoid, they both present on x-ray as a bony mass with a radiolucent core.

Osteoid Osteoma forms smaller lesions in long bones. The bone pain is usually worse at night and improves with NSAIDs use.

Osteoblastoma forms larger lesions, usually in the vertebrae. The pain is not worse at night (when compared to day) and is not responsive to NSAIDs. Since the pain does not improve with medication, osteoblastomas are treated surgically to alleviate the pain.

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