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Neurological Disorders

Glioblastoma Multiforme (Grade IV Astrocytoma)

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Glioblastoma Multiforme (GBM), also known as Grade IV Astroyctoma, is an invasive brain tumor of adults that arises from astrocytes, a type of glial cell in the brain.

Glioblastoma is highly malignant and aggressive tumor found in the cerebral hemispheres that can cross the corpus callosum, giving a "butterfly-like" lesion on imaging. The prognosis is extremely poor, with <1 year average life expectancy.

Gross pathology will reveal a variegated appearance with mixed tumor, necrosis, hemorrhage, and cystic areas. Due to its astrocytic origin, GBM stains positively for GFAP (glial fibrillary acidic protein). Histologicaly, "psuedopalisading" pleomorphic tumor cells border central areas of necrosis and hemorrhage. Microvascular proliferation and hemorrhage are common features.

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