Down Syndrome (Trisomy 21)
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Down syndrome (also known as trisomy 21) is a genetic disorder caused most often by a meiotic nondisjunction of chromosome 21. It may also be caused by a Robertsonian translocation--or less commonly by mosaicism. It is characterized by a number of clinical findings, such as epicanthal folds, a simian crease, brushfield spots, and more.