Ivabradine
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Cardiovascular Drugs (New)
- Ivabradine
- Nitroprusside
- DHP Calcium Channel Blockers
- Hydralazine
- Fenoldopam
- Nitrates
- Ranolazine
- Sacubitril
Summary
Ivabradine is a medication used to treat chest pain and heart failure. It works by blocking funny sodium channels in pacemaker cells. This prolongs the slow depolarization of the cell, causing a lengthening of phase 4 of the pacemaker action potential. Side effects of ivabradine include seeing luminous phenomena and bradycardia. Hypertension may also occur as a rare side effect.
Key Points
- Ivabradine
- Mechanism
- Selective inhibition of funny sodium channels (IF)
- Prolongs the slow depolarization phase (phase 4) of the pacemaker action potential
- This decreases SA and AV nodal activity, leading to negative chronotropy and dromotropy without affecting inotropy
- This works to reduce myocardial oxygen demands
- Clinical Use
- Treats heart failure
- Used to treat chronic heart failure with reduced ejection fraction
- Treats angina
- Reduction in myocardial oxygen demand can treat angina
- Used as second-line anti-anginal treatment, in patients who cannot take B-blockers
- Treats heart failure
- Side Effects
- Luminous phenomena / visual brightness
- Due to inhibition of ion channels in the retina that are similar to funny channels
- Hypertension
- Bradycardia
- Luminous phenomena / visual brightness
- Mechanism