Medicine & USMLE


Cardio Drugs - Blood Pressure
  1. ACE Inhibitors
  2. Angiotensin II Receptor Blockers (ARBs)
  3. Beta Blockers: Mechanisms and Clinical Uses
  4. Beta Blockers: Side Effects
  5. DHP Calcium Channel Blockers
  6. Hydralazine
  7. Aliskiren
  8. Nitroprusside
  9. Alpha-1 Blockers
  10. Clonidine


Aliskiren is a direct renin inhibitor that is used to treat hypertension.

It can cause hyperkalemia as a side effect, so potassium levels should be monitored during treatment. Aliskiren is teratogenic and should not be taken during pregnancy. Other side effects include angioedema and diarrhea.

Aliskiren should not be taken with high fat foods.

Key Points

  • Aliskiren (Tekturna)
    • Drug Class
      • Direct Renin Inhibitor
        • By blocking renin, the blood vessels relax and the body produces less angiotensin, leading to lower blood pressure
    • Clinical Use
      • Treats Hypertension
    • Side Effects
      • Angioedema
        • Swelling of the face, especially around the eyes, mouth, and tongue
        • Can become extremely dangerous if the swelling blocks the airway
      • Hyperkalemia
        • Monitor potassium levels during treatment
      • Diarrhea
        • Dose-related
      • Teratogenic
        • Avoid in patients who are pregnant or are planning to become pregnant
    • Nursing Considerations
      • Do not take with high-fat foods
        • High fat foods decrease the medication’s absorption and effectiveness