Isotretinoin

Summary

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Key Points

• Isotretinoin (Accutane)
  • Mechanism
    • Vitamin A derivative 
      • Vitamin A supplements should be avoided to avoid toxicity
  • Clinical Use
    • Severe acne
      • Used when acne is unresponsive to other treatment
  • Side Effects and Adverse Reactions
    • Teratogenic
      • Pregnancy category X
      • Negative pregnancy test is required before start of treatment
      • Use two forms of birth control during treatment
      • Patients taking isotretinoin shouldn’t donate blood to avoid the risk of giving blood with the drug to a pregnant woman
    • Skin sensitivity
      • Dryness of skin, mouth, and eyes
      • Skin irritation
      • Photosensitivity (sunburn)
      • Common, expected side effects
    • Muscle damage
    • Dizziness
    • Headache