Pilocarpine

Summary

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Key Points

• Pilocarpine (Pilocar, Isopto Carpine)
  • Mechanism
    • Cholinergic Drug
      • Mimics the effect of acetylcholine
  • Clinical Uses
    • Glaucoma
      • Constricts the pupils (miosis), opening the Schlemm canal and thus promoting drainage of aqueous humor (fluid)
      • Decreases ocular pressure
    • Xerostomia (dry mouth)
      • When given orally
  • Side Effects and Adverse Reactions
    • Cholinergic Side Effects
      • Systemic side effects are not very common when given via eye drops but symptoms of systemic absorption include:
        • Urinary frequency
        • Diarrhea
        • Lacrimation
        • Diaphoresis
        • Bradycardia
        • Hypotension