USMLE

Orlistat

9 views
GI Drugs
  1. Ondansetron
  2. Sucralfate
  3. Docusate (Stool Softener)
  4. Bulk Forming Laxatives (Psyllium, Methylcellulose)
  5. Stimulant Laxatives (Senna, Bisacodyl)
  6. Bismuth Subsalicylate
  7. Antidiarrheals (Loperamide, Diphenoxylate-Atropine)
  8. Antacids
  9. Metoclopramide
  10. Misoprostol
  11. Proton Pump Inhibitors (PPIs)
  12. Orlistat
  13. Octreotide

Summary

Coming soon...

Key Points

  • Orlistat (Xenical)
    • Mechanism
      • Lipase inhibitor
        • Reduces GI fat absorption
    • Clinical Use
      • Weight loss
        • To be taken with meals
    • Side Effects and Adverse Reactions
      • Steatorrhea
        • Fatty, oily bowel movements due to reduced GI fat absorption (more fat in feces)
        • Patients may be prescribed psyllium to reverse adverse GI effects
      • Vitamin deficiency
        • Can reduce the absorption of fat-soluble vitamins like Vitamins A, D, E, and K
        • These vitamins should be supplemented in patients taking orlistat