Orlistat
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GI Drugs
- Ondansetron
- Metoclopramide
- Antacids
- Proton Pump Inhibitors (PPIs)
- H2 Blockers
- Bismuth Subsalicylate
- Sucralfate
- Misoprostol
- Docusate (Stool Softener)
- Bulk Forming Laxatives (Psyllium, Methylcellulose)
- Osmotic Laxatives (Lactulose, PEG)
- Stimulant Laxatives (Senna, Bisacodyl)
- Antidiarrheals (Loperamide, Diphenoxylate-Atropine)
- Orlistat
- Octreotide
Summary
Orlistat is a weight loss medication that works by reducing fat absorption in the gut. Side effects include steatorrhea, or fatty, greasy stools. Orlistat also can cause vitamin deficiencies of the fat-soluble vitamins A, D, E, and K. These vitamins should be supplemented during orlistat treatment.
Key Points
- Orlistat (Xenical)
- Mechanism
- Lipase inhibitor
- Reduces GI fat absorption
- Lipase inhibitor
- Clinical Use
- Weight loss
- To be taken with meals
- Weight loss
- Side Effects and Adverse Reactions
- Steatorrhea
- Fatty, oily bowel movements due to reduced GI fat absorption (more fat in feces)
- Patients may be prescribed psyllium to reverse adverse GI effects
- Vitamin deficiency
- Can reduce the absorption of fat-soluble vitamins like Vitamins A, D, E, and K
- These vitamins should be supplemented in patients taking orlistat
- Steatorrhea
- Mechanism