USMLE

Sucralfate

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GI Drugs
  1. Ondansetron
  2. Sucralfate
  3. Docusate (Stool Softener)
  4. Bulk Forming Laxatives (Psyllium, Methylcellulose)
  5. Stimulant Laxatives (Senna, Bisacodyl)
  6. Bismuth Subsalicylate
  7. Antidiarrheals (Loperamide, Diphenoxylate-Atropine)
  8. Antacids
  9. Metoclopramide
  10. Misoprostol
  11. Proton Pump Inhibitors (PPIs)
  12. Orlistat
  13. Octreotide

Summary

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Key Points

  • Sucralfate (Carafate)
    • Mechanism
      • Drug class: Pepsin inhibitor (Mucosal Protectant)
        • Combines with a protein to create a protective layer over the gastrointestinal wall, specifically to prevent or protect ulcers
    • Clinical Use
      • Ulcer Treatment and Prevention
        • Usually prescribed 1 hour before meals and at bedtime
        • Best on an empty stomach
    • Side Effects and Adverse Reactions
      • Drug Interactions
        • Alters absorption of other oral medications
        • Should not be given at the same time as other medications
      • Constipation
        • Most common side effect
      • Systemic side effects are usually very minor because the drug is not absorbed from the GI tract
        • Dry mouth
        • Headaches
        • Dizziness
        • Drowsiness