Docusate (Stool Softener)
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GI Drugs
- Ondansetron
- Sucralfate
- Docusate (Stool Softener)
- Bulk Forming Laxatives (Psyllium, Methylcellulose)
- Osmotic Laxatives (Lactulose, PEG)
- Stimulant Laxatives (Senna, Bisacodyl)
- Antidiarrheals (Loperamide, Diphenoxylate-Atropine)
- Bismuth Subsalicylate
- Antacids
- Proton Pump Inhibitors (PPIs)
- H2 Blockers
- Metoclopramide
- Misoprostol
- Orlistat
- Octreotide
Summary
Docusate is a stool softener that is used to treat and prevent constipation. If used in excess, it can cause diarrhea.
Key Points
- Stool Softeners
- Also called surfactant laxatives
- Key Drugs
- Docusate
- Docusate sodium (Colace)
- Docusate calcium
- Docusate
- Mechanism
- Reduces surface tension of the stool to allow for water and fat to permeate and soften the stool, hence the name “stool softeners”
- Clinical Use
- Constipation
- Often prescribed along with opioids, as opioids can cause constipation
- Prevention of straining
- Often prescribed post-abdominal surgery to prevent wound dehiscence associated with straining
- May also be prescribed post-myocardial infarction, as preventing straining is thought to be helpful in reducing the workload of the heart
- Constipation
- Side Effects and Adverse Reactions
- Mild cramping
- Bitter taste, throat irritation