Ondansetron
2,006 views
GI Drugs
- Ondansetron
- Metoclopramide
- Antacids
- Proton Pump Inhibitors (PPIs)
- H2 Blockers
- Bismuth Subsalicylate
- Sucralfate
- Misoprostol
- Docusate (Stool Softener)
- Bulk Forming Laxatives (Psyllium, Methylcellulose)
- Osmotic Laxatives (Lactulose, PEG)
- Stimulant Laxatives (Senna, Bisacodyl)
- Antidiarrheals (Loperamide, Diphenoxylate-Atropine)
- Orlistat
- Octreotide
Summary
Ondansetron is a medication used to treat nausea and vomiting. As a serotonin receptor blocker, it can cause an abnormality in serotonin signaling known as serotonin syndrome, which is a life-threatening medical emergency that presents with unstable vitals, muscle rigidity, as well as agitation and restlessness.
Key Points
- Ondansetron (Zofran)
- Mechanism
- Serotonin (5-HT3) antagonist
- Blocks the serotonin receptors in the chemoreceptor trigger zone (CZ)
- Blocks the afferent vagal neurons in the upper GI tract
- Serotonin (5-HT3) antagonist
- Clinical Uses
- Nausea and vomiting
- Chemotherapy
- Postoperative recovery
- Treat n/v side effects of anesthesia and narcotics
- Prevent dehiscence and evisceration of wounds associated with abdominal strain from vomiting
- Nausea and vomiting
- Side Effects and Adverse Reactions
- Serotonin Syndrome
- By blocking the serotonin receptors, more serotonin is in the synapses and can lead to serotonin syndrome
- Muscle rigidity, restlessness, agitation, tachycardia
- Headache
- Most common side effect
- Prolonged QT interval
- Can lead to torsade de Pointes
- Monitor heart rhythm in patients with present cardiac disorders
- If giving IV, give slowly over 2-5 minutes
- Hypotension
- Dizziness
- Serotonin Syndrome
- Mechanism