Hemophilia C
3,174 views
Coagulation
- Common Pathway of Coagulation
- Extrinsic Pathway of Coagulation
- Intrinsic Pathway of Coagulation
- Hemophilia A
- Hemophilia B
- Hemophilia C
- Factor V Leiden
- Antithrombin-3 Deficiency
Summary
Coming soon...
Key Points
- Hemophilia C
- Pathogenesis
- Deficiency of Factor XI
- Genetics
- Autosomal recessive inheritance
- Presentation
- Clinical symptoms are usually milder in this syndrome vs. Hemophilias A or B
- Mild bleeding
- Usually only detected with prolonged bleeding after trauma or surgery
- Diagnosis
- Definitive: Factor XI levels
- Elevated PTT
- Due to inhibited intrinsic coagulation pathway
- Normal PT
- Extrinsic (tissue factor) pathway is unaffected
- Normal Bleeding Time
- Platelet plug formation (primary hemostasis is unaffected)
- Treatment
- Recombinant Factor XI concentrate
- Pathogenesis