Medicine & USMLE

Pregabalin

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Neuro Drugs
  1. Levodopa, Carbidopa
  2. Levetiracetam
  3. Valproic Acid
  4. Anticholinergic Syndrome
  5. Cholinergic Crisis
  6. Benztropine / Trihexyphenidyl
  7. Lidocaine
  8. Pyridostigmine, Neostigmine, Edrophonium
  9. Naltrexone
  10. Pregabalin
  11. Scopolamine
  12. Phenytoin
  13. Ethosuximide
  14. Succinylcholine
  15. Opioids
  16. Memantine
  17. Halothane / Flurane
  18. Donepezil
  19. Propofol
  20. Ergotamine
  21. Triptans
  22. Selegiline / Rasagiline
  23. Entacapone / Tolcapone
  24. Gabapentin
  25. Lamotrigine
  26. Carbamazepine
  27. Ramelteon

Summary

Pregabalin is a medication primarily used to treat nerve pain. As an anticonvulsant drug, it can also be used in combination with other medications to treat seizures. It’s most important side effects are sedation and drowsiness.

Key Points

  • Pregabalin (Lyrica)
    • Mechanism
      • GABA analog, nonopioid analgesic
        • Binds to calcium channels in the CNS to regulate neurotransmitter release
    • Clinical Use
      • Neuropathic pain
        • Fibromyalgia
        • Diabetic neuropathy
        • Postherpetic neuralgia
      • Seizures
        • Effective in treating partial seizures
    • Side Effects and Adverse Reactions
      • Sedation/Drowsiness
        • Avoid activities that require alertness (e.g. driving) until the effects of the medication are known
      • Dizziness
      • Weight gain
      • Dry mouth
      • Edema
      • Blurred vision
      • Thrombocytopenia (low platelets)