Medicine & USMLE

Ethosuximide

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Neuro Drugs
  1. Levodopa, Carbidopa
  2. Levetiracetam
  3. Valproic Acid
  4. Anticholinergic Syndrome
  5. Cholinergic Crisis
  6. Benztropine / Trihexyphenidyl
  7. Lidocaine
  8. Pyridostigmine, Neostigmine, Edrophonium
  9. Naltrexone
  10. Pregabalin
  11. Scopolamine
  12. Phenytoin
  13. Ethosuximide
  14. Succinylcholine
  15. Memantine
  16. Donepezil
  17. Halothane / Flurane
  18. Propofol
  19. Ergotamine
  20. Triptans
  21. Selegiline / Rasagiline
  22. Entacapone / Tolcapone
  23. Gabapentin
  24. Lamotrigine
  25. Carbamazepine
  26. Ramelteon

Summary

Ethosuximide is an anticonvulsant drug used to treat absence seizures. GI distress in the form of nausea or vomiting is the most common side effect. Ethosuximide may rarely cause Stevens-Johnson syndrome, so be sure to report any signs of a rash.

Key Points

  • Ethosuximide (Zarontin)
    • Mechanism
      • Anticonvulsant
        • Decreases calcium influx through the calcium channels, preventing the rapid repetitive firing that occurs during a seizure
    • Clinical Use
      • Absence Seizures
        • Also called petit mal seizures
        • A form of generalized seizure that is brief and sudden, and often manifests as a blank stare
    • Side Effects and Adverse Reactions
      • Gastrointestinal distress
        • Abdominal pain, nausea, vomiting, anorexia
      • Rash
        • May develop into Steven Johnson syndrome
      • Headache
      • Dizziness
      • Drowsiness, Fatigue