Medicine & USMLE

Ethosuximide

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Neuro Drugs
  1. Levodopa, Carbidopa
  2. Levetiracetam
  3. Valproic Acid
  4. Anticholinergic Syndrome
  5. Cholinergic Crisis
  6. Benztropine / Trihexyphenidyl
  7. Lidocaine
  8. Pyridostigmine, Neostigmine, Edrophonium
  9. Naltrexone
  10. Pregabalin
  11. Scopolamine
  12. Phenytoin
  13. Ethosuximide
  14. Succinylcholine
  15. Opioids
  16. Memantine
  17. Halothane / Flurane
  18. Donepezil
  19. Propofol
  20. Ergotamine
  21. Triptans
  22. Selegiline / Rasagiline
  23. Entacapone / Tolcapone
  24. Gabapentin
  25. Lamotrigine
  26. Carbamazepine
  27. Ramelteon

Summary

Ethosuximide is an anticonvulsant drug used to treat absence seizures. GI distress in the form of nausea or vomiting is the most common side effect. Ethosuximide may rarely cause Stevens-Johnson syndrome, so be sure to report any signs of a rash.

Key Points

  • Ethosuximide (Zarontin)
    • Mechanism
      • Anticonvulsant
        • Decreases calcium influx through the calcium channels, preventing the rapid repetitive firing that occurs during a seizure
    • Clinical Use
      • Absence Seizures
        • Also called petit mal seizures
        • A form of generalized seizure that is brief and sudden, and often manifests as a blank stare
    • Side Effects and Adverse Reactions
      • Gastrointestinal distress
        • Abdominal pain, nausea, vomiting, anorexia
      • Rash
        • May develop into Steven Johnson syndrome
      • Headache
      • Dizziness
      • Drowsiness, Fatigue