Medicine & USMLE

Triptans

109 views
Neuro Drugs
  1. Levodopa, Carbidopa
  2. Levetiracetam
  3. Valproic Acid
  4. Anticholinergic Syndrome
  5. Cholinergic Crisis
  6. Benztropine / Trihexyphenidyl
  7. Lidocaine
  8. Pyridostigmine, Neostigmine, Edrophonium
  9. Naltrexone
  10. Pregabalin
  11. Scopolamine
  12. Phenytoin
  13. Ethosuximide
  14. Succinylcholine
  15. Memantine
  16. Donepezil
  17. Halothane / Flurane
  18. Propofol
  19. Ergotamine
  20. Triptans
  21. Selegiline / Rasagiline
  22. Entacapone / Tolcapone
  23. Gabapentin
  24. Lamotrigine
  25. Carbamazepine
  26. Ramelteon

Summary

Triptans are a class of medications easily recognizable by their triptan ending. Sumatriptan is the most common drug in this class, but other drug names include zolmitriptan and rizatriptan. The triptans are clinically used to treat the pain associated with migraine headaches.

Key Points

  • Triptans
    • Key Drugs
      • Sumatriptan
      • Zolmitriptan
      • Rizatriptan
    • Mechanism
      • Serotonin (5-HT) receptor agonist
        • Causes vasoconstriction of cerebral arteries
          • Contraindicated in patients with history of stroke
        • Blocks release of substance P and other vasoactive molecules that cause headache
    • Clinical Use
      • Migraine headache
        • Often given in combination with an NSAID
        • Helps to stop pain (abortive treatment) after onset of acute headache
      • Cluster headaches
    • Side Effects and Adverse Reactions
      • Dizziness
      • Drowsiness
      • Dry mouth
      • Nausea, vomiting
      • Fatigue, weakness