USMLE

Triptans

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Neuro Drugs
  1. Pyridostigmine, Neostigmine, Edrophonium
  2. Valproic Acid
  3. Naltrexone
  4. Levetiracetam
  5. Pregabalin
  6. Scopolamine
  7. Phenytoin
  8. Ethosuximide
  9. Levodopa, Carbidopa
  10. Succinylcholine
  11. Memantine
  12. Donepezil
  13. Halothane / Flurane
  14. Propofol
  15. Ergotamine
  16. Triptans
  17. Selegiline / Rasagiline
  18. Entacapone / Tolcapone
  19. Gabapentin
  20. Lamotrigine
  21. Carbamazepine
  22. Mannitol
  23. Ramelteon

Summary

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Key Points

  • Triptans
    • Key Drugs
      • Sumatriptan
      • Zolmitriptan
      • Rizatriptan
    • Mechanism
      • Serotonin (5-HT) receptor agonist
        • Causes vasoconstriction of cerebral arteries
          • Contraindicated in patients with history of stroke
        • Blocks release of substance P and other vasoactive molecules that cause headache
    • Clinical Use
      • Migraine headache
        • Often given in combination with an NSAID
        • Helps to stop pain (abortive treatment) after onset of acute headache
      • Cluster headaches
    • Side Effects and Adverse Reactions
      • Dizziness
      • Drowsiness
      • Dry mouth
      • Nausea, vomiting
      • Fatigue, weakness