Triptans
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Neuro Drugs
- Anticholinergic Syndrome
- Cholinergic Crisis
- Benztropine / Trihexyphenidyl
- Pyridostigmine, Neostigmine, Edrophonium
- Donepezil
- Memantine
- Scopolamine
- Levodopa, Carbidopa
- Selegiline / Rasagiline
- Entacapone / Tolcapone
- Propofol
- Halothane / Flurane
- Opioids
- Succinylcholine
- Lidocaine
- Ergotamine
- Triptans
- Pregabalin
- Gabapentin
- Ramelteon
Summary
Triptans are a class of medications easily recognizable by their triptan ending. Sumatriptan is the most common drug in this class, but other drug names include zolmitriptan and rizatriptan. The triptans are clinically used to treat the pain associated with migraine headaches.
Key Points
- Triptans
- Key Drugs
- Sumatriptan
- Zolmitriptan
- Rizatriptan
- Mechanism
- Serotonin (5-HT) receptor agonist
- Causes vasoconstriction of cerebral arteries
- Contraindicated in patients with history of stroke
- Blocks release of substance P and other vasoactive molecules that cause headache
- Causes vasoconstriction of cerebral arteries
- Serotonin (5-HT) receptor agonist
- Clinical Use
- Migraine headache
- Often given in combination with an NSAID
- Helps to stop pain (abortive treatment) after onset of acute headache
- Cluster headaches
- Migraine headache
- Side Effects and Adverse Reactions
- Dizziness
- Drowsiness
- Dry mouth
- Nausea, vomiting
- Fatigue, weakness
- Key Drugs