Selegiline / Rasagiline
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Neuro Drugs
- Levodopa, Carbidopa
- Levetiracetam
- Valproic Acid
- Anticholinergic Syndrome
- Cholinergic Crisis
- Benztropine / Trihexyphenidyl
- Lidocaine
- Pyridostigmine, Neostigmine, Edrophonium
- Naltrexone
- Pregabalin
- Scopolamine
- Phenytoin
- Ethosuximide
- Succinylcholine
- Opioids
- Memantine
- Halothane / Flurane
- Donepezil
- Propofol
- Ergotamine
- Triptans
- Selegiline / Rasagiline
- Entacapone / Tolcapone
- Gabapentin
- Lamotrigine
- Carbamazepine
- Ramelteon
Summary
Selegiline and Rasagiline are a type of MAOIs, or monoamine oxidase drugs that work to increase the amount of dopamine signaling in the brain. They are used clinically to treat Parkinson’s Disease.
Key Points
- Selegiline (Eldepryl), Rasagiline
- Mechanism
- MAO Inhibitor
- Inhibition of monoamine oxidase type B (MAO-B), which prevents breakdown of dopamine in the brain
- Prolongs the length that dopamine is available in the synapses
- Slows the deterioration of dopaminergic nerve cells
- MAO Inhibitor
- Clinical Use
- Parkinson Disease
- Used for early treatment to delay the need for levodopa
- Parkinson Disease
- Side Effects and Adverse Reactions
- Drug interactions
- MAOIs and SSRIs
- Insomnia
- If possible, avoid taking in the evening
- Hypertensive crisis
- At doses over 10 mg/day selegiline becomes a nonselective MAOI and reacts with tyramine to cause a hypertensive crisis
- Avoid tyramine-containing foods
- Cheese, pepperoni, wine
- Drug interactions
- Mechanism