Medicine & USMLE

Selegiline / Rasagiline

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Neuro Drugs
  1. Anticholinergic Syndrome
  2. Cholinergic Crisis
  3. Benztropine / Trihexyphenidyl
  4. Pyridostigmine, Neostigmine, Edrophonium
  5. Donepezil
  6. Memantine
  7. Scopolamine
  8. Levodopa, Carbidopa
  9. Selegiline / Rasagiline
  10. Entacapone / Tolcapone
  11. Propofol
  12. Halothane / Flurane
  13. Opioids
  14. Succinylcholine
  15. Lidocaine
  16. Ergotamine
  17. Triptans
  18. Pregabalin
  19. Gabapentin
  20. Ramelteon

Summary

Selegiline and Rasagiline are a type of MAOIs, or monoamine oxidase drugs that work to increase the amount of dopamine signaling in the brain. They are used clinically to treat Parkinson’s Disease.

Key Points

  • Selegiline (Eldepryl), Rasagiline
    • Mechanism
      • MAO Inhibitor
        • Inhibition of monoamine oxidase type B (MAO-B), which prevents breakdown of dopamine in the brain
        • Prolongs the length that dopamine is available in the synapses
        • Slows the deterioration of dopaminergic nerve cells
    • Clinical Use
      • Parkinson Disease
        • Used for early treatment to delay the need for levodopa
    • Side Effects and Adverse Reactions
      • Drug interactions
        • MAOIs and SSRIs
      • Insomnia
        • If possible, avoid taking in the evening
      • Hypertensive crisis
        • At doses over 10 mg/day selegiline becomes a nonselective MAOI and reacts with tyramine to cause a hypertensive crisis
        • Avoid tyramine-containing foods
          • Cheese, pepperoni, wine