USMLE

Selegiline / Rasagiline

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Neuro Drugs
  1. Pyridostigmine, Neostigmine, Edrophonium
  2. Valproic Acid
  3. Naltrexone
  4. Levetiracetam
  5. Pregabalin
  6. Scopolamine
  7. Phenytoin
  8. Ethosuximide
  9. Levodopa, Carbidopa
  10. Succinylcholine
  11. Memantine
  12. Donepezil
  13. Halothane / Flurane
  14. Propofol
  15. Ergotamine
  16. Triptans
  17. Selegiline / Rasagiline
  18. Entacapone / Tolcapone
  19. Gabapentin
  20. Lamotrigine
  21. Carbamazepine
  22. Mannitol
  23. Ramelteon

Summary

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Key Points

  • Selegiline (Eldepryl), Rasagiline
    • Mechanism
      • MAO Inhibitor
        • Inhibition of monoamine oxidase type B (MAO-B), which prevents breakdown of dopamine in the brain
        • Prolongs the length that dopamine is available in the synapses
        • Slows the deterioration of dopaminergic nerve cells
    • Clinical Use
      • Parkinson Disease
        • Used for early treatment to delay the need for levodopa
    • Side Effects and Adverse Reactions
      • Drug interactions
        • MAOIs and SSRIs
      • Insomnia
        • If possible, avoid taking in the evening
      • Hypertensive crisis
        • At doses over 10 mg/day selegiline becomes a nonselective MAOI and reacts with tyramine to cause a hypertensive crisis
        • Avoid tyramine-containing foods
          • Cheese, pepperoni, wine