USMLE

Propofol

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Neuro Drugs
  1. Pyridostigmine, Neostigmine, Edrophonium
  2. Valproic Acid
  3. Naltrexone
  4. Levetiracetam
  5. Pregabalin
  6. Scopolamine
  7. Phenytoin
  8. Ethosuximide
  9. Levodopa, Carbidopa
  10. Succinylcholine
  11. Memantine
  12. Donepezil
  13. Halothane / Flurane
  14. Propofol
  15. Ergotamine
  16. Triptans
  17. Selegiline / Rasagiline
  18. Entacapone / Tolcapone
  19. Gabapentin
  20. Lamotrigine
  21. Carbamazepine
  22. Mannitol
  23. Ramelteon

Summary

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Key Points

  • Propofol (Diprivan)
    • Mechanism
      • Non-barbiturate Sedative
        • Binds to GABA receptors to depress the CNS
      • Administered via IV
    • Clinical Use
      • Sedation / Anesthesia
        • Used to keep ventilated patients sedated
        • Used as part of an anesthetic regimen
    • Side Effects and Adverse Reactions
      • Respiratory depression
        • Closely monitor respiratory rate, which should be at least 12 breaths per minute
      • Cardiovascular depression
        • Hypotension and bradycardia
        • Closely monitor heart rate and blood pressure
      • Increased Risk For Bacterial infection
        • Propofol supports microbial growth
      • Propofol Infusion Syndrome (PRIS)
        • Rare, but extremely dangerous
        • Associated with prolonged high doses
        • Metabolic acidosis, cardiac arrhythmias, hyperkalemia, lipemia, hepatomegaly, acute kidney injury