Medicine & USMLE

Propofol

82 views
Neuro Drugs
  1. Levodopa, Carbidopa
  2. Levetiracetam
  3. Valproic Acid
  4. Anticholinergic Syndrome
  5. Cholinergic Crisis
  6. Benztropine / Trihexyphenidyl
  7. Lidocaine
  8. Pyridostigmine, Neostigmine, Edrophonium
  9. Naltrexone
  10. Pregabalin
  11. Scopolamine
  12. Phenytoin
  13. Ethosuximide
  14. Succinylcholine
  15. Memantine
  16. Donepezil
  17. Halothane / Flurane
  18. Propofol
  19. Ergotamine
  20. Triptans
  21. Selegiline / Rasagiline
  22. Entacapone / Tolcapone
  23. Gabapentin
  24. Lamotrigine
  25. Carbamazepine
  26. Ramelteon

Summary

Propofol is a drug that is often used as a general anesthetic during surgery, but is also used for its sedative effects in the ICU setting. Notably, the drug can slow down both the respiratory and cardiovascular systems, causing respiratory depression, a low blood pressure, and a slow heart rate. As the nurse, be sure to closely monitor these vital signs and notify the provider if they fall below a normal range.

Key Points

  • Propofol (Diprivan)
    • Mechanism
      • Non-barbiturate Sedative
        • Binds to GABA receptors to depress the CNS
      • Administered via IV
    • Clinical Use
      • Sedation / Anesthesia
        • Used to keep ventilated patients sedated
        • Used as part of an anesthetic regimen
    • Side Effects and Adverse Reactions
      • Respiratory depression
        • Closely monitor respiratory rate, which should be at least 12 breaths per minute
      • Cardiovascular depression
        • Hypotension and bradycardia
        • Closely monitor heart rate and blood pressure
      • Increased Risk For Bacterial infection
        • Propofol supports microbial growth
      • Propofol Infusion Syndrome (PRIS)
        • Rare, but extremely dangerous
        • Associated with prolonged high doses
        • Metabolic acidosis, cardiac arrhythmias, hyperkalemia, lipemia, hepatomegaly, acute kidney injury