USMLE

Ergotamine

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Neuro Drugs
  1. Pyridostigmine, Neostigmine, Edrophonium
  2. Valproic Acid
  3. Naltrexone
  4. Levetiracetam
  5. Pregabalin
  6. Scopolamine
  7. Phenytoin
  8. Ethosuximide
  9. Levodopa, Carbidopa
  10. Succinylcholine
  11. Memantine
  12. Donepezil
  13. Halothane / Flurane
  14. Propofol
  15. Ergotamine
  16. Triptans
  17. Selegiline / Rasagiline
  18. Entacapone / Tolcapone
  19. Gabapentin
  20. Lamotrigine
  21. Carbamazepine
  22. Mannitol
  23. Ramelteon

Summary

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Key Points

  • Ergotamine (Ergomar)
    • Mechanism
      • Ergot alkaloids
        • Block adrenergic receptors, causing peripheral vasoconstriction
    • Clinical Use
      • Migraines
        • Often combined with caffeine
        • Should be administered at the onset of aura or headache
    • Side Effects and Adverse Reactions
      • Contraindicated with vasospasm (e.g. Prinzmetal angina, Raynaud phenomenon)
      • Gastrointestinal distress
        • Nausea, vomiting
      • Physical dependence
        • Is not intended to be taken daily, only at the onset of a migraine headache
        • Withdrawal symptoms include migraine-like symptoms (headache, nausea, vomiting, restlessness)
      • Teratogenic
        • Pregnancy Category X