USMLE

Carbamazepine

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Neuro Drugs
  1. Pyridostigmine, Neostigmine, Edrophonium
  2. Valproic Acid
  3. Naltrexone
  4. Levetiracetam
  5. Pregabalin
  6. Scopolamine
  7. Phenytoin
  8. Ethosuximide
  9. Levodopa, Carbidopa
  10. Succinylcholine
  11. Memantine
  12. Donepezil
  13. Halothane / Flurane
  14. Propofol
  15. Ergotamine
  16. Triptans
  17. Selegiline / Rasagiline
  18. Entacapone / Tolcapone
  19. Gabapentin
  20. Lamotrigine
  21. Carbamazepine
  22. Mannitol
  23. Ramelteon

Summary

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Key Points

  • Carbamazepine (Tegretol)
    • Mechanism
      • Drug class: Anticonvulsants
        • Blocks sodium channels, stabilizing the rapid firing that occurs during seizure activity
    • Clinical Uses
      • Trigeminal Neuralgia
        • Severe facial pain involving the trigeminal nerve (cranial nerve V)
        • Also used for other neuropathic pain syndromes
      • Seizures
        • Tonic-clonic and partial seizures
      • Bipolar Disorder
    • Side Effects and Adverse Reactions
      • Agranulocytosis
        • Black box warning
        • Low white blood cell count
        • Increased risk of infection
        • Report signs of fever or sore throat
        • Patient will require monthly CBC monitoring
      • Steven-Johnson’s Syndrome
        • Black box warning
        • Report signs of rash
      • Food-drug interactions may cause carbamazepine toxicity
        • Avoid grapefruit juice
        • Avoid benzodiazepines