USMLE

Memantine

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Neuro Drugs
  1. Pyridostigmine, Neostigmine, Edrophonium
  2. Valproic Acid
  3. Naltrexone
  4. Levetiracetam
  5. Pregabalin
  6. Scopolamine
  7. Phenytoin
  8. Ethosuximide
  9. Levodopa, Carbidopa
  10. Succinylcholine
  11. Memantine
  12. Donepezil
  13. Halothane / Flurane
  14. Propofol
  15. Ergotamine
  16. Triptans
  17. Selegiline / Rasagiline
  18. Entacapone / Tolcapone
  19. Gabapentin
  20. Lamotrigine
  21. Carbamazepine
  22. Mannitol
  23. Ramelteon

Summary

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Key Points

  • Memantine (Namenda)
    • Mechanism
      • NMDA receptor antagonist
        • Binds to NMDA receptors, blocking the neurotransmitter glutamate which then prevents calcium from building up in the brain cells.
    • Clinical Uses
      • Alzheimer Disease
        • Memantine is not a cure, but slows the progression of the disease
    • Side Effects and Adverse Reactions
      • Stevens Johnson Syndrome
        • Report symptoms of a rash immediately
      • Sedation, drowsiness
      • Dizziness
      • Constipation
      • Headaches