Medicine & USMLE

Lamotrigine

232 views
Neuro Drugs
  1. Levodopa, Carbidopa
  2. Levetiracetam
  3. Valproic Acid
  4. Anticholinergic Syndrome
  5. Cholinergic Crisis
  6. Benztropine / Trihexyphenidyl
  7. Lidocaine
  8. Pyridostigmine, Neostigmine, Edrophonium
  9. Naltrexone
  10. Pregabalin
  11. Scopolamine
  12. Phenytoin
  13. Ethosuximide
  14. Succinylcholine
  15. Opioids
  16. Memantine
  17. Halothane / Flurane
  18. Donepezil
  19. Propofol
  20. Ergotamine
  21. Triptans
  22. Selegiline / Rasagiline
  23. Entacapone / Tolcapone
  24. Gabapentin
  25. Lamotrigine
  26. Carbamazepine
  27. Ramelteon

Summary

Lamotrigine is a medication used to treat seizures as well as bipolar disorder. An important adverse effect is a life-threatening drug rash called Stevens-Johnson Syndrome, so any signs of a rash should be reported immediately. Another common side effect is drowsiness or sedation.

Key Points

  • Lamotrigine (Lamictal)
    • Mechanism
      • Drug class: Anticonvulsants/Anti Seizure
        • Blocks voltage-gated sodium channels
    • Clinical Use
      • Seizures
        • Can treat partial and generalized seizures
      • Bipolar disorder
        • First line treatment
    • Side Effects and Adverse Reactions
      • Rash / Stevens-Johnson Syndrome
        • Any signs of a rash should be immediately reported to the provider
      • Sedation, fatigue, dizziness
        • Acts to depress CNS activity at sodium channels
      • Gastrointestinal distress
        • May be taken with food to reduce GI distress