USMLE

Entacapone / Tolcapone

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Neuro Drugs
  1. Pyridostigmine, Neostigmine, Edrophonium
  2. Valproic Acid
  3. Naltrexone
  4. Levetiracetam
  5. Pregabalin
  6. Scopolamine
  7. Phenytoin
  8. Ethosuximide
  9. Levodopa, Carbidopa
  10. Succinylcholine
  11. Memantine
  12. Donepezil
  13. Halothane / Flurane
  14. Propofol
  15. Ergotamine
  16. Triptans
  17. Selegiline / Rasagiline
  18. Entacapone / Tolcapone
  19. Gabapentin
  20. Lamotrigine
  21. Carbamazepine
  22. Mannitol
  23. Ramelteon

Summary

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Key Points

  • Entacapone (Comtam), Tolcapone (Tasmar)
    • Mechanism
      • Catechol-O-Methyltransferase (COMT) inhibitor
        • Inhibits an enzyme that inactivates dopamine, thus increasing the amount of dopamine in the brain
    • Clinical Uses
      • Parkinson’s Disease
        • Used alongside levodopa/carbidopa, so that a smaller dose of levodopa can be used
    • Side Effects and Adverse Reactions
      • Orthostatic hypotension
        • Rise slowly to avoid sudden dizziness
      • Orange urine discoloration
        • An expected, harmless side effect
      • Hepatotoxicity (tolcapone only)
        • Monitor liver enzymes