USMLE

Rasburicase

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Musculoskeletal Drugs
  1. Azathioprine
  2. Corticosteroids
  3. Sulfasalazine
  4. TNF Inhibitors
  5. Immunosuppressants (Cyclosporine, Mycophenolate, Tacrolimus)
  6. Acetaminophen
  7. NSAIDs
  8. Colchicine
  9. Allopurinol
  10. Rasburicase
  11. Dantrolene
  12. Muscle Relaxants
  13. Bisphosphonates: Alendronate, Risedronate

Summary

Rasburicase is a medication that lowers uric acid levels. This can be used to treat patients experiencing tumor lysis syndrome, a form of gout caused by the release of uric acid by dying cancer cells.

Key Points

  • Mechanism
    • Lowers uric acid levels
      • Converts uric acid to allantoin, which dissolves well in water and is excreted in the urine
    • Clinical Use
      • Treats tumor lysis syndrome (TLS)