GPIIb/IIIa Inhibitors (Abciximab, Tirofiban, Eptifibatide)

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Summary

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Key Points

  • Drug Names
    • Abciximab
    • Tirofiban
    • Eptifibatide
    • Mechanism
      • Antiplatelet
        • Block the binding of fibrinogen to the platelet
        • Antiplatelet effects of abciximab last up to 10 days after the infusion. Effects of tirofiban and eptifibatide last up to 4 hours after the infusion.
    • Clinical Use
      • Prevent clot formation
        • During percutaneous coronary intervention (PCI), a procedure where a catheter is inserted to open an occluded coronary artery
        • During acute coronary conditions like unstable angina and acute myocardial infarction
    • Side Effects and Adverse Reactions
      • Bleeding
        • Due to thrombocytopenia (low platelet count)
        • The nurse should be acutely aware of signs of internal bleeding, like hypotension, tachycardia, blood in stools or urine, change in heart rhythm, abdominal/back pain, and change in mental status.
        • Avoid any unnecessary invasive procedures, including needle sticks (IV insertion, IM injections, etc.)
        • Closely monitor CBC levels