Progressive Supranuclear Palsy
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Neurodegenerative Diseases
- Alzheimer Dementia
- Vascular Dementia
- Lewy Body Dementia
- Frontotemporal Dementia
- Parkinson Disease
- Multiple System Atrophy
- Progressive Supranuclear Palsy
- Creutzfeldt-Jakob Disease
Progressive Supranuclear Palsy
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Summary
Progressive supranuclear palsy is caused by neurodegeneration of the midbrain and frontal subcortical white matter. Patients with PSP present with vertical gaze palsy, dementia, and parkinsonism. Finally, progressive supranuclear palsy involves abnormal deposits of hyperphosphorylated tau proteins in the brain cells.
Key Points
- Progressive Supranuclear Palsy (PSP)
- Cause
- Unknown etiology
- Neurodegeneration of the midbrain and frontal subcortical white matter
- Presentation
- Vertical gaze palsy
- Inability or limited range of movements in looking up and down
- Parkinsonism
- Gait instability and falls
- Dementia
- Cognitive impairment
- Vertical gaze palsy
- Neuropathology
- Shows deposits of abnormally phosphorylated tau proteins
- Cause