Mesocortical Pathway
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Dopaminergic Pathways
Mesocortical Pathway
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Summary
The mesocortical pathway is a dopaminergic pathway that connects the midbrain to the cortex. It plays key roles in cognition, motivation, and emotion, and is inhibited or downregulated in patients with schizophrenia and other psychotic disorders.
Key Points
- Mesocortical Pathway
- Dopaminergic Pathway
- Connects the midbrain (ventral tegmentum) to the cortex (prefrontal cortex)
- Function
- Thought to be involved in:
- Cognition
- Motivation
- Emotion
- Thought to be involved in:
- Lesions
- Inhibited in Schizophrenia (and other psychotic disorders)
- leads to negative symptoms (flat affect, apathy, anergia, lack of spontaneity)
- Antipsychotic drugs have limited effect
- Inhibited in Schizophrenia (and other psychotic disorders)
- Dopaminergic Pathway