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Key Points

  • Mechanism
    • Granulocyte colony-stimulating factor (G-CSF)
      • Stimulates the production of neutrophils, a type of white blood cell
    • Clinical Use
      • Leukopenia
        • Filgrastim is used to treat low white blood cell counts, especially low neutrophil counts (neutropenia)
        • Often used in patients undergoing chemotherapy
    • Side Effects and Adverse Reactions
      • Headache, rash, and epistaxis
      • Skeletal pain
        • Joint pain, muscle pain, and bone pain
      • Hypertension