USMLE

Filgrastim

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Hematology Drugs
  1. Dabigatran / Argatroban
  2. Factor Xa Inhibitors (Rivaroxaban, Apixaban)
  3. Heparin
  4. Low Molecular Weight Heparins (Enoxaparin, Fondaparinux, Dalteparin)
  5. Warfarin
  6. Aspirin
  7. GPIIb/IIIa Inhibitors (Abciximab, Tirofiban, Eptifibatide)
  8. Alteplase / tPA
  9. Iron
  10. Filgrastim
  11. Epoetin Alfa

Summary

Filgrastim is a medication used to treat leukopenia or neutropenia in patients. It works to increase the number of neutrophils in the body, and is most commonly used to combat a lowering of white blood cell counts associated with chemotherapy.

Key Points

  • Mechanism
    • Granulocyte colony-stimulating factor (G-CSF)
      • Stimulates the production of neutrophils, a type of white blood cell
    • Clinical Use
      • Leukopenia
        • Filgrastim is used to treat low white blood cell counts, especially low neutrophil counts (neutropenia)
        • Often used in patients undergoing chemotherapy
    • Side Effects and Adverse Reactions
      • Headache, rash, and epistaxis
      • Skeletal pain
        • Joint pain, muscle pain, and bone pain
      • Hypertension