Trastuzumab
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Anti-Neoplastic Drugs
- Cyclophosphamide
- Methotrexate
- Tamoxifen
- Cisplatin
- Doxorubicin
- Imatinib
- Paclitaxel
- Rituximab
- Trastuzumab
- Vincristine
Summary
Trastuzumab is a medication used to treat HER-2 positive breast cancer. Side effects include cardiotoxicity, specifically heart failure. Trastuzumab may also cause an infusion related reaction that lessens over time with subsequent infusions.
Key Points
- Trastuzumab
- Mechanism
- Binds to and inhibits the human epidermal growth factor 2 (HER-2)
- Clinical Use
- Breast Cancer
- Endometrial and ovarian cancer
- Colon cancer
- Side Effects and Adverse Reactions
- Cardiotoxicity
- Heart failure
- Monitor for signs of heart failure such as fluid retention/edema
- Heart failure
- Infusion-related reaction
- Initial infusion may cause headache, dizziness, hypotension, fever, chills, and nausea. These symptoms will diminish with each subsequent infusion.
- Pulmonary toxicity
- Headache
- Muscle ache
- Loss of appetite
- Cardiotoxicity
- Mechanism