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Key Points

  • Rituximab
    • Mechanism
      • Monoclonal antibody against CD20
        • CD20 is a protein marker expressed on surface of B cells
    • Clinical Use
      • Cancers
        • Lymphomas
        • Leukemias
      • Rheumatoid arthritis/Anti-inflammatory
    • Side Effects and Adverse Reactions
      • Infusion Reaction Syndrome
        • Hypotension
        • Tachycardia
        • Shortness of breath
        • Rash
        • If the patient experiences an infusion reaction syndrome, the nurse should stop the infusion, notify the provider, and be prepared to administer epinephrine, steroids, and oxygen if needed.
      • Since rituximab is targeted therapy, general chemotherapy side effects (alopecia, bone marrow suppression, and GI disturbances) are minimal compared to other chemotherapy medications.
      • Hyperglycemia
      • Tumor lysis syndrome