Medicine & USMLE

Imatinib

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Cancer Drugs
  1. General Chemo Side Effects
  2. Busulfan
  3. Cyclophosphamide
  4. Methotrexate
  5. Tamoxifen
  6. Cisplatin
  7. Doxorubicin
  8. Imatinib
  9. Paclitaxel
  10. Rituximab
  11. Trastuzumab
  12. Vincristine

Summary

Imatinib is a chemotherapy drug used to treat chronic myeloid leukemia, or CML. It’s most important side effect is fluid retention and edema.

Key Points

  • Imatinib, nilotinib, dasatinib
    • Mechanism
      • Tyrosine kinase inhibitor
        • Targets BCR-ABL fusion protein that is the cause of certain cancers like CML
    • Clinical Uses
      • Cancer / Chemotherapy
        • Chronic myeloid leukemia (CML)
        • Acute Lymphoblastic leukemia (ALL)
    • Side Effects and Adverse Reactions
      • Edema and fluid retention