USMLE

Imatinib

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Anti-Neoplastic Drugs
  1. Cyclophosphamide
  2. Methotrexate
  3. Tamoxifen
  4. Cisplatin
  5. Doxorubicin
  6. Imatinib
  7. Paclitaxel
  8. Rituximab
  9. Trastuzumab
  10. Vincristine

Summary

Imatinib is a chemotherapy drug used to treat chronic myeloid leukemia, or CML. It’s most important side effect is fluid retention and edema.

Key Points

  • Imatinib, nilotinib, dasatinib
    • Mechanism
      • Tyrosine kinase inhibitor
        • Targets BCR-ABL fusion protein that is the cause of certain cancers like CML
    • Clinical Uses
      • Cancer / Chemotherapy
        • Chronic myeloid leukemia (CML)
        • Acute Lymphoblastic leukemia (ALL)
    • Side Effects and Adverse Reactions
      • Edema and fluid retention