Pioglitazone
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Anti-Diabetic Drugs
- Insulin Overview
- Rapid Acting Insulin
- Short Acting Insulin
- Intermediate Acting Insulin
- Long Acting Insulin
- Metformin
- Sulfonylureas
- Canagliflozin
- Pioglitazone
Summary
Pioglitazone is an antidiabetic drug that is used to lower blood sugar in patients with type 2 diabetes. Pioglitazone works by lowering insulin resistance, so it actually has a low risk for causing hypoglycemia. Pioglitazone’s main adverse effect is cardiovascular toxicity, meaning there is a chance the pioglitazone causes a myocardial infarction or heart failure.
Key Points
- Pioglitazone
- Mechanism
- Thiazolidinediones
- Decrease insulin resistance and increase blood glucose control
- Carry a low risk for hypoglycemia (similar to metformin)
- Thiazolidinediones
- Clinical Uses
- Hyperglycemia in Type 2 Diabetes Mellitus
- Side Effects and Adverse Reactions
- Cardiovascular Toxicity
- Myocardial Infarction
- Heart Failure
- Can worsen pre-existing heart failure by causing fluid retention
- Bladder Cancer
- Cardiovascular Toxicity
- Mechanism