USMLE

Canagliflozin

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Anti-Diabetic Drugs
  1. Insulin Overview
  2. Rapid Acting Insulin
  3. Short Acting Insulin
  4. Intermediate Acting Insulin
  5. Long Acting Insulin
  6. Metformin
  7. Sulfonylureas
  8. Canagliflozin
  9. Pioglitazone

Summary

Canagliflozin is a medication used to lower blood sugar levels in patients with type 2 diabetes. It lowers blood sugar in the body by increasing the amount of sugar excreted in the urine. This can lead to side effects like urinary tract infections.

Key Points

  • Canagliflozin, Dapagliflozin
    • Mechanism
      • Sodium-glucose cotransporter inhibitors (SGLT2 Inhibitors)
        • Promotes urinary glucose loss
    • Clinical Uses
      • Hyperglycemia in Type 2 Diabetes Mellitus
        • Taken in combination with control of diet and exercise
    • Side Effects and Adverse Reactions
      • Problems with the urinary tract
        • Cystitis (bladder infection) and other urinary tract infections (UTIs)
        • Urinary urgency & frequency
        • Nocturia
      • Female genital infections
        • Vaginal candidiasis