Long Acting Insulin

16

Summary

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Key Points

  • Long Acting Insulin
    • Drug Names
      • Glargine (Lantus)
      • Detemir (Levemir)
    • Onset, Peak, Duration
      • Onset = 1-2 hours
      • Peak = ~1 day (no peak)
        • Exact peak for detemir depends on patient and ranges from 4-9 hours
        • Glargine’s peak is so slow and long (>12 h) that there is no apparent peak in dose
      • Duration = up to 24 hours
    • Nursing Considerations
      • Cannot be mixed
        • Never mix long-acting insulins with other insulin formulations (e.g. regular insulin)
      • Inject once daily, at the same time each day
      • Given to prevent, not correct, hyperglycemia
        • Long peak is intended to counteract baseline production of glucose by liver