USMLE

Rapid Acting Insulin

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Anti-Diabetic Drugs
  1. Insulin Overview
  2. Rapid Acting Insulin
  3. Short Acting Insulin
  4. Intermediate Acting Insulin
  5. Long Acting Insulin
  6. Metformin
  7. Sulfonylureas
  8. Canagliflozin
  9. Pioglitazone

Summary

Rapid-acting insulins include the drugs aspart, lispro, and glulisine. These insulins work the fastest among all insulin types, with a peak around 30 minutes after administration. Clinically, rapid-acting insulins are usually given with meals to counteract the blood sugar spike that occurs after eating.

Key Points

  • Rapid Acting Insulin
    • Drug Names
      • Aspart (Novolog)
      • Lispro (Humalog)
      • Glulisine (Apidra)
    • Onset, Peak, Duration
      • Onset = 10-15 minutes
      • Peak = ~30 minutes
        • Exact peak depends on patient and ranges from 30 minutes - 3 hours
      • Duration = 3-5 hours
    • Nursing Considerations
      • Give with meals
        • Rapid onset of these insulins is able to counteract postprandial (after meal or food-related) glucose spikes
      • Used on a sliding scale to correct hyperglycemia quickly