Trazodone (Old)
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Summary
Trazodone is an atypical antidepressant drug used to treat depression. Side effects of the drug include orthostatic hypotension, sedation, and priapism.
Key Points
- Mechanism
- Atypical antidepressant
- Increases serotonin levels in the brain
- Blocks alpha and H1 receptors
- Clinical Use
- Depression
- Atypical antidepressant thought to work by modulating serotonin and catecholamine signaling
- Often used in combination therapy with another antidepressant
- Insomnia
- Used off label due to sedative side effect
- Due to blockade of H1 receptors in the brain
- Depression
- Side Effects and Adverse Reactions
- Priapism
- Prolonged painful erection (>2 hours) that can lead to tissue hypoxia and necrosis if not treated immediately
- Medical emergency
- Drowsiness/Sedation
- Take at night to avoid daytime sleepiness
- Should not be taken with other CNS depressants (benzodiazepines, alcohol, antihistamines, etc.)
- Orthostatic Hypotension
- Advise patient to rise slowly to avoid sudden drop in blood pressure
- Older patients are at higher risk for falls
- Priapism
- Atypical antidepressant
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