Nystatin
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Anti-Infective Drugs
- Vancomycin
- Metronidazole
- Penicillins
- Cephalosporins
- Macrolides
- Fluoroquinolones
- Aminoglycosides
- Tetracyclines
- Sulfonamides
- Rifampin
- Isoniazid
- Ethambutol
- Chloroquine
- Acyclovir
- Oseltamivir
- Azoles
- Nystatin
- Amphotericin B
Summary
Nystatin is an antifungal medication that is used to treat candidiasis, also called a yeast infection or thrush. Nystatin can be applied topically with an ointment, cream, or powder. It can also be administered orally with a lozenge or a swish-and-swallow solution.
Key Points
- Nystatin
- Mechanism
- Antifungal
- Binds to ergosterol to form holes in fungal membranes, causing fungal cell leakage and death
- ***Note: ends in “-statin” but is NOT a statin (cholesterol) medication.
- Antifungal
- Clinical Use
- Candida fungal infections
- Oral/esophageal candidiasis
- Administered as a liquid “swish and swallow” suspension that should be swished around the mouth and then swallowed
- May also be administered as a lozenge that the patient should let dissolve completely in mouth
- Topical yeast infections
- Administered topically as an ointment, cream, or powder
- Oral/esophageal candidiasis
- Candida fungal infections
- Side Effects and Adverse Reactions
- Skin irritation (topical application)
- Nausea and vomiting (oral administration)
- May interfere with oral contraceptives
- Teach patient to use additional contraception
- Mechanism